T. Culbreth, Distributor
LIFE PLUS™ at The Olive Branch

Nutritional Supplements "from a company whose president is a pharmacist"

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BONE BUILDER™
120 tablets $29.50

How can I support the way my body maintains healthy calcium levels?

There are some important elements that may affect the way your body uses calcium. To help you get the most out of our supplements, we included synergistic compounds that prepare your body for proper calcium absorption and utilization. We’ve included ipriflavone, a leading edge nutrient only recently available, that promotes the healthy process of incorporating calcium into bone. Also included is vanadium, which is a bone-seeking, ultra-trace mineral, folic acid, vitamin B-12 and a special metabolite of vitamin B-6, which all support healthy calcium and bone metabolism. The Bone Builder formula also contains a highly absorbable form of calcium, as a calcium citrate/malate carbonate complex. People of all ages should support healthy bones with regular exercise, and a healthy diet including sufficient calcium.

Supplement Facts

Serving Size

2 Tablets

Servings Per Container (120 tablets)

60

Amount Per Serving

% Daily Value

Folic Acid

200

mcg

50%

Vitamin B-12 (Cyanocobalamin)

100

mcg

1667%

Calcium (Total)

205

mg

21%

Ipriflavone

300

mg

*

Pyridoxal 5-Phosphate

15

mg

*

Vanadium (as Vanadyl Sulfate)

50

mcg

*

*Daily Value not established

INGREDIENTS:  Calcium Citrate Malate Carbonate Complex, Ipriflavone, Dicalcium Phosphate, Stearic Acid, Silica, Microcrystalline Cellulose, Pyridoxal 5-Phosphate, Croscarmellose Sodium, Magnesium Stearate, Vitamin B-12 (Cyanocobalamin), Vanadyl Sulfate, Folic Acid, and PhytoZyme™ proprietary blend (Bromelain, Papain, Aloe Vera, Alfalfa, Parsley, and vegetable and fruit concentrates from Carrots, Broccoli, Spinach, Cauliflower, Asparagus, Celery, Beet, Chili Pepper, Green Bean, Pea, Sweet Potato, Cucumber, Pumpkin, Snow Pea, Tomato, Zucchini, Lima Beans, Mushroom, Banana, Cantaloupe, Cranberry, Guava, Lemon, Mango, Orange, Papaya, Peach, Pineapple and Grapefruit).

Calcium Promotes Bone Health

Bone Builder is a high quality nutritional supplement based on the isoflavone derivative ipriflavone. Small amounts of ipriflavone occurs naturally in many foods.   More than 60 double- blind placebo controlled clinical studies, involving over 3,000 participants in Italy, Japan, and Hungary, have shown that ipriflavone, along with calcium and vitamin D, significantly promotes bone health and strong bones.

In many studies, ipriflavone was found to help maintain the bone. It appears to promote the incorporation of calcium into bone and positively support the natural balance required to maintain healthy bones. Bone Builder supplies 600 mg of ipriflavone daily, the amount used in nearly all of the nutritional research in humans with this isoflavone.

Promotes Bone Formation

An in vitro (laboratory tissue culture research)  examination of the effect of ipriflavone and its metabolites on healthy bones resulted in interesting findings. Ipriflavone and one of its metabolites increased alkaline phosphatase activity (an enzyme used by osteoblast cells to lay down more calcium and phosphorus in bone), while another metabolite enhanced collagen formation, which is the protein foundation of bone.

Contains More Absorbable Calcium

Bone Builder also contains a unique form of calcium called calcium citrate malate carbonate complex (CCMC), which is a mixture of calcium combined primarily with citric acid and malic acid. Both of these organic acids are also involved in key energy producing pathways in the body.

Nutritional research has consistently shown that CCMC provides superior calcium absorption over other single forms of calcium; this formula provides extra elemental calcium in this form in two tablets taken twice daily.

Vanadium is an ultra-trace element, which occurs in the average diet in amounts of 15-30 micrograms per day. Research suggests that it plays a role in building bones and teeth. Bone Builder supplies 100 micrograms of vanadium per day.

Population studies have generally found that these three B vitamins  help lower homocysteine levels in the blood, though it has not yet been substantiated as to whether this will have an impact on bone or cardiovascular health in the long term.

A whole foods diet rich in fruits, vegetables, high quality protein, high quality essential fats, and pure water, plus an active lifestyle, combined with Bone Builder will provide powerful tools for the maintenance of bone health that can last a lifetime.

DIRECTIONS:  Two tablets twice a day.

Formulated in the exclusive PhytoZyme™ base of plant enzymes for bioavailability and over 30 synergistic fruit, vegetable and herbal concentrates for "extra" phytonutrient cofactors.

Contains no artificial preservatives, sugar, starch, caffeine, salt, wheat, gluten, yeast, corn, milk, egg, shellfish, soya derivatives, artificial sweetening, flavoring or coloring agents.

Contains no ingredients from animal sources and is not tested on animals.

References:
1. Tsutsumi N, Kawashima K, Nagata H, et al. Effects of KCA-098 on bone metabolism: comparison with those of ipriflavone. Jpn J Pharmacol 1994; 65
2. Benvenuti S, Tanini A, Frediani U, et al. Effects of ipriflavone and its metabolites on a clonal osteoblastic cell line. J Bone Miner Res 1991; 6
3. Agnusdei D, Gennari C, Bufalino L. Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone. Osteoporosis Int 1995; 5
4. Sato Y. Abnormal bone and calcium metabolism in patients after stroke. Arch Phys Med Rehabil 2000 Jan; 81 (1)
5. Bostom AG, Silbershatz IH, Rosenberg IH, et al. Non-fasting plasma total homocysteine levels and all cause and cardiovascular disease mortality in elderly Framingham men and women. Arch Intern Med 1999; 159:1077-80
6. Amano R, Enomoto S, Nobuta M, et al. Bone uptake of vanadium in mice: simultaneous tracing of V, Se, Sr, Y, Zr, Ru, and Rh using a radioactive multitracer. J Trace Elem Med Biol 1996  Sep;10(3):145-8.
7. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61:S23-S27
8. Krumdieck CL, Prince CW. Mechanisms of homocysteine toxicity on connective tissues:  implications for the morbidity of aging.  J Nutr 2000 Feb;130(2S /syook):354S-368S
9. Miller J, Smith D, Flora L, et al. Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. Am J Clin Nutr 1988;48:1291–4.

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T. Culbreth, Independent Distributor - On the Net since 1996
Life Plus Corporate Office, Batesville, Arkansas 72503